The countdown to Christmas is on, and so is the countdown to the end of the 2024 NFL regular season. The playoff race has intensified all over the league, making this a very popular time in the sports year for football betting.
As we already know from last week, the byes are over. Week 16 is fully-loaded, with 16 games lined up including a handful of big divisional tilts. Broncos vs. Chargers — a battle of postseason hopefuls — kicks things off on Thursday Night Football in LA, with surging Denver getting three points against Jim Harbaugh’s team.
MORE: Updated power rankings | Playoff picture | Updated draft order
Will we see Patrick Mahomes this week? That will be the storyline of Saturday’s early game, as the Chiefs face the Texans hoping to maintain top-seed positioning over MVP favorite Josh Allen and the Bills in the AFC. Steelers-Ravens in the latter half of Saturday’s doubleheader will also be of monumental importance to the final standings.
As for the NFC, Eagles-Commanders stands out in the early slate, a battle between Rookie of the Year frontrunner Jayden Daniels and Offensive Player of the Year favorite Saquon Barkley. Vikings-Seahawks will be huge, too, with Sam Darnold trying to keep Minnesota in the running for top seed now that the Lions finally lost a second game. And don’t sleep on the Packers (vs. Saints)!
Let’s get to the moneyline, spread, and over/under odds for every matchup on the Week 16 schedule. Good luck, have fun, and be sure to read our best bets and top props throughout the week!
NFL Week 16 odds: Lines, spreads, over/under totals
All odds courtesy of BetMGM Sportsbook.
| Day/time (ET) | Game | ML | ATS | O/U |
| Thu., 12/19 8:15 p.m. |
Broncos @ Chargers |
LAC -160 DEN +135 |
LAC -3 (-110) DEN +3 (-110) |
O 42.5 (-110) U 42.5 (-110) |
| Sun., 12/21 1:00 p.m. |
Chiefs @ Browns |
HOU -140 KC +115 |
HOU -2.5 (-115) KC +2.5 (-105) |
O 40.5 (-110) U 40.5 (-110) |
| Sun., 12/21 1:00 p.m. |
Steelers @ Ravens |
BAL -275 PIT +225 |
BAL -6.5 (-115) PIT +6.5 (-105) |
O 46.5 (-110) U 46.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Giants @ Falcons |
ATL -550 NYG +400 |
ATL -10 (-110) NYG +10 (-110) |
O 42.5 (-110) U 42.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Patriots @ Bills |
BUF -900 NE +600 |
BUF -14 (-110) NE +14 (-110) |
O 46.5 (-110) U 46.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Lions @ Bears |
DET -375 CHI +300 |
DET -7.5 (-115) CHI +7.5 (-105) |
O 46.5 (-110) U 46.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Browns @ Bengals |
CIN -350 CLE +260 |
CIN -7 (-105) CLE +7 (-115) |
O 49.5 (-110) U 49.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Titans @ Colts |
IND -225 TEN +180 |
IND -4.5 (-110) TEN +4.5 (-110) |
O 42.5 (-110) U 42.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Rams @ Jets |
LAR -165 NYJ +140 |
LAR -3 (-115) NYJ +3 (-105) |
O 47.5 (-110) U 47.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Eagles @ Commanders |
PHI -190 WAS +155 |
PHI -4 (-110) WAS +4 (-110) |
O 45.5 (-110) U 45.5 (-110) |
| Sun., 12/22 1:00 p.m. |
Cardinals @ Panthers |
ARI -225 CAR +180 |
ARI -4.5 (-110) CAR +4.5 (-110) |
O 46.5 (-110) U 46.5 (-110) |
| Sun., 12/22 4:05 p.m. |
Vikings @ Seahawks |
MIN -225 SEA +185 |
MIN -4.5 (-110) SEA +4.5 (-110) |
O 47.5 (-110) U 47.5 (-110) |
| Sun., 12/22 4:25 p.m. |
Jaguars @ Raiders |
LV -120 JAX +100 |
LV -1.5 (+100) JAX +1.5 (-120) |
O 39.5 (-110) U 39.5 (-110) |
| Sun., 12/22 4:25 p.m. |
49ers @ Dolphins |
MIA -140 SF +115 |
MIA -2.5 (-110) SF +2.5 (-110) |
O 46.5 (-110) U 46.5 (-110) |
| Sun., 12/22 8:20 p.m. |
Buccaneers @ Cowboys |
TB -200 DAL +165 |
TB -4.5 (-105) DAL +4.5 (-115) |
O 48.5 (-110) U 48.5 (-110) |
| Mon., 12/23 8:15 p.m. |
Saints @ Packers |
GB -750 NO +525 |
GB -13.5 (-105) NO +13.5 (-115) |
O 42.5 (-110) U 42.5 (-110) |
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