Is Kyler Murray playing this week? Latest news, updates on Cardinals QB’s status for Week 6 vs. Colts

After recording back-to-back wins to start the season, the Arizona Cardinals have been struck by a familiar stupor. The Cards dropped three straight games by a combined margin of defeat by five points.

Star quarterback Kyler Murray’s early-season heroics have given way to inconsistency. He struggled mightily in Arizona’s defeat to the Seattle Seahawks in Week 4 and was at the helm when the Cardinals blew an 18-point advantage en route to a defeat to the Tennessee Titans in Week 5.

The latter matchup proved particularly disastrous for Murray, who was temporarily left on the sideline after incurring a foot injury.

Here’s the latest on Murray’s recent injury woes — and if it could impact his status for the Cardinals’ next game, a Week 6 tilt with the Indianapolis Colts.

MORE: How much money has Kyler Murray made in career?

Is Kyler Murray playing this week?

Murray is unlikely to play for the Cardinals in Week 6. ESPN’s Adam Schefter reported Saturday that Jacoby Brissett was in line to start for Arizona, while Ian Rapoport reported the Cardinals are “leaving the door open” for Murray to play, but “preparing” for Brissett to start.

Murray’s injury is described as a “mid-foot sprain” and version of a Lisfranc injury, per Rapoport. There is also reportedly a possibility of him missing further time.

Murray did not participate in practice on Thursday, per Schefter, which increased concerns about his availability to start. He then returned to the practice field on Friday, two days before the Cardinals Week 6 game against the Indianapolis Colts.

After missing the past two days of practice due to a foot injury, Cardinals QB Kyler Murray is practicing today.

— Adam Schefter (@AdamSchefter) October 10, 2025

The former No. 1 overall pick was temporarily cut down with a foot injury during the Cardinals’ Week 5 contest with the Tennessee Titans. Murray left the game, briefly taking to the locker room. Brissett played two snaps in relief before Murray returned to the game.

Arizona surrendered a 21-3 lead in the second, falling victim to a pair of fumbles and some late-game Titans fireworks. After the Cardinals’ defeat, Murray spoke with the media regarding the nature of his ailment. “We gotta see,” Murray said.

When addressing the media, head coach Jonathan Gannon said Murray’s status would be decided over the following days. However, as the Cardinals also elevated quarterback Kedon Slovis from their practice squad on Saturday, the signs haven’t encouraging for Murray’s status.

Murray isn’t expected to play in Week 6, although Rapoport did note that the Cardinals are “keeping the door open” if his foot heals in time for the game. If not, Brissett will get the start.

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Kyler Murray injury update

Murray exited Sunday’s game briefly after injuring his foot in the third quarter. He went to the sidelines, then the locker room, before returning to the game after two snaps.

Murray was listed with a foot injury. According to Rapoport, Murray’s injury is a “mid-foot sprain and “a version of a Lisfranc injury.”

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Cardinals remaining schedule 2025

After the Cardinals travel to Indianapolis, they’ll return to action against the Packers in Week 7. They’ll get a bye week in Week 8 before getting back on the field against the Cowboys on “Monday Night Football.”